A na-ere Dutasteride n'ụzọ ọgwụ dị ka Avodart, Avidart, Avolve, Duagen, Dutas, Dutagen, Duprost.Maka ihe ndị a na-amaghị, nnwale ụlọ ọgwụ nke mbụ maka dutasteride kwụsịrị na mberede na 2002, wee gaa n'ihu mgbe e mesịrị.

Dutasteride bụ 5-alpha-reductase inhibitor, nke pụtara na ọ na-egbochi ọrụ nke 5a-reducase enzymes, nke na-ahụ maka 5a-reducing (na-atụgharị) testosterone n'ime dihydrotestosterone (DHT) site na mgbakwunye nke njikọ hydrogen abụọ.

Dutasteride na-egbochi ma isoforms nke 5a-reductase, ya mere na-egbochi ntụgharị nke testosterone n'ime dihydrotestosterone.Nke a na-eme Dutasteride ka ọ bụrụ ọgwụgwọ ezi uche dị na ya maka isi nkwọcha nwoke.N'ezie, mgbe ị na-agbanwe obere Testosterone n'ime Dihydrotestosterone, ị na-abawanye ọkwa testosterone site na ndabara (obere ntụgharị).

Dutasteride, na 2.5mgs / ụbọchị bụ ihe dị ka 1.5x dị irè karịa Finasteride na 5mgs / ụbọchị, na-emeso ntutu isi (ha abụọ na-akwụsị ya yana ịmaliteghachi ya).Tụkwasị na nke ahụ, a pụrụ iji Dutasteride mee ihe nke ọma n'otu ọgwụ ahụ iji na-emeso mmụba prostate, na mmetụta dị nta nke Dutasteride (ọzọ, n'otu dose ahụ) na-eji ya eme ihe bụ ịgwọ Acne nke oke androgens na-eme n'ime ahụ.

Maka steroid na-eji ndị na-eme egwuregwu na-ata ahụhụ site na mmetụta ndị metụtara DHT, Dutasteride nwere ike ịbụ azịza ya.Ọkpụkpụ ntutu, otutu, na uto prostate nwere ike kwụsị kpamkpam (nwere ike) site na iji ngwaahịa a.N'ụzọ dị mwute, DHT abụghị ihe ọjọọ niile, na ị nwere ike idafu ụfọdụ anụ ahụ ike ike (ihe amorphous àgwà ma ọ bụrụ na e nwere otu), na ọbụna ụfọdụ n'ime àgwà ndị ọzọ na-amasị anyị site na anyị androgen ojiji.

Ọzọkwa ... ebe ọ bụ na nke a na-egbochi 5a-mbelata nke androgens n'okpuru ntụgharị ahụ n'ime ụdị dihydro nke ha ... ọ gaghị eme ihe ọ bụla iji kwụsị ntutu isi ma ọ bụ mgbaàmà ndị ọzọ kpatara kpamkpam site na iji androgens na ezinụlọ DHT.

Dutasteride, tinyere Finasteride bụ 5-alpha-Reductase inhibitor nke bụ otu ọgwụ ndị nwere ihe mgbochi-androgenic nke na-egbochi ntụgharị nke testosterone n'ime dihydrotestosterone (DHT).Nke a bụ otu kemịkalụ ahụ dị na Proscar na Propecia ma jiri ya na ọgwụgwọ hyperplasia na androgenic alopecia.N'ihi na ọgwụ ndị a na-ebelata ọkwa dihydrotestosterone (DHT) ha na-eji egbochi ma na-agwọ ntutu isi.A na-ejikarị agwọ ọrịa prostate glands.